SLC6A3

Across TCGA cell cohorts, SLC6A3 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,061 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible SLC6A3-associated GO terms across cancer lineages are Regulation of myoblast fusion, Regulation of transcription elongation by RNA polymerase II, and Regulation of vacuole organization. Each is linked with SLC6A3 in more than 6 cancer types. Because this analysis shows association rather than direction, both SLC6A3-to-partner and partner-to-SLC6A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of myoblast fusion grouped by SLC6A3-low versus SLC6A3-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC6A3→partner) and Y-score (partner→SLC6A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Regulation of myoblast fusion →	+0.110	+0.078	<.001	<.001	3	6
UPPER_AERODIGESTIVE_TRACT	Regulation of transcription elongation by RNA polymerase II →	+0.050	+0.051	.001	.002	3	6
UPPER_AERODIGESTIVE_TRACT	Regulation of vacuole organization →	+0.054	+0.079	.003	.007	3	6
LUNG_SCLC	Establishment of protein localization to organelle →	+0.047	+0.983	<.001	.006	3	6
UPPER_AERODIGESTIVE_TRACT	Positive regulation of macroautophagy →	+0.052	+0.045	.001	.007	3	6
UPPER_AERODIGESTIVE_TRACT	Negative regulation of myoblast fusion →	+0.125	+0.079	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,061 associations by consensus.

Regulation of myoblast fusion by SLC6A3 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →