SLC6A3

Across TCGA cell cohorts, SLC6A3 mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SLC6A3-associated genes across cancer lineages are IQCF5, OR2A2, and USP17L15. Each is linked with SLC6A3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC6A3-to-partner and partner-to-SLC6A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IQCF5 grouped by SLC6A3-low versus SLC6A3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC6A3→partner) and Y-score (partner→SLC6A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	IQCF5 →	+0.135	+5.201	<.001	.006	3	2
URINARY_TRACT	OR2A2 →	+0.035	+4.087	<.001	.009	3	1
OESOPHAGUS	USP17L15 →	+0.136	+4.906	<.001	.006	3	1
LUNG_SCLC	OR4C3 →	+0.073	+5.643	<.001	.002	3	1
LUNG_SCLC	TMIGD1 →	+0.088	+5.029	<.001	.006	3	1
BLOOD_Leukemia	NKX2-6 →	+0.663	+5.201	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

IQCF5 by SLC6A3 expression — BLOOD_Leukemia

Explore this box plot interactively →