SLC6A2

Across TCGA patient cohorts, SLC6A2 mutation is significantly associated with the RNA expression of many other genes, with 3,574 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC6A2-associated genes across cancer lineages are DCPS, SLBP, and SCNN1B. Each is linked with SLC6A2 in more than 3 cancer types. Because this analysis shows association rather than direction, both SLC6A2-to-partner and partner-to-SLC6A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DCPS grouped by SLC6A2-low versus SLC6A2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC6A2→partner) and Y-score (partner→SLC6A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DCPS →	+0.419	+2.512	.003	.009	3	4
UCEC	SLBP →	+0.524	+2.148	<.001	<.001	3	3
UCEC	SCNN1B →	-1.399	-2.137	.001	.001	3	3
UCEC	ING2 →	+0.488	+1.850	<.001	.002	3	3
UCEC	RRM2 →	+0.729	+2.330	.001	.003	3	3
UCEC	EXO1 →	+0.548	+1.773	.007	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,574 associations by consensus.

DCPS by SLC6A2 expression — UCEC

Explore this box plot interactively →