SLC6A19

Across TCGA patient cohorts, SLC6A19 mutation is significantly associated with the RNA expression of many other genes, with 2,528 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC6A19-associated genes across cancer lineages are KIFBP, RPL23AP53, and WDR7. Each is linked with SLC6A19 in more than 3 cancer types. Because this analysis shows association rather than direction, both SLC6A19-to-partner and partner-to-SLC6A19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KIFBP grouped by SLC6A19-low versus SLC6A19-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC6A19→partner) and Y-score (partner→SLC6A19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	KIFBP →	+0.403	+1.885	.005	.004	3	3
COAD	RPL23AP53 →	+0.528	+2.235	<.001	.006	3	3
COAD	WDR7 →	+0.329	+3.200	.006	.009	3	3
COAD	SIRT1 →	+0.468	+2.527	.002	.009	3	3
UCEC	CCSER2 →	+0.533	+2.917	<.001	<.001	3	3
UCEC	MCM9 →	+0.290	+2.510	.008	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,528 associations by consensus.

KIFBP by SLC6A19 expression — SKCM

Explore this box plot interactively →