SLC6A19

Across TCGA cell cohorts, SLC6A19 mutation is significantly associated with the RNA expression of many other genes, with 556 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLC6A19-associated genes across cancer lineages are POU4F2, PLA2G3, and GCAT. Each is linked with SLC6A19 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC6A19-to-partner and partner-to-SLC6A19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, POU4F2 grouped by SLC6A19-low versus SLC6A19-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC6A19→partner) and Y-score (partner→SLC6A19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	POU4F2 →	+0.005	+1.861	.009	.005	3	2
LARGE_INTESTINE	PLA2G3 →	+0.873	+3.710	.001	<.001	3	1
LARGE_INTESTINE	GCAT →	+1.371	+3.459	<.001	<.001	3	1
LARGE_INTESTINE	EIF3L →	+0.474	+3.389	.003	.001	3	1
LARGE_INTESTINE	CBY1 →	+0.551	+2.129	.001	.007	3	1
LARGE_INTESTINE	JOSD1 →	+0.466	+2.043	.007	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 556 associations by consensus.

POU4F2 by SLC6A19 expression — LARGE_INTESTINE

Explore this box plot interactively →