SLC6A14

Across TCGA pan-cancer cohorts, SLC6A14 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SLC6A14 data layer compared with 25 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher SLC6A14 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SLC6A14 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

LUAD, HNSC, and UCEC are the cancer types where SLC6A14 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	0.781	1.000	.009	15	view →
HNSC	OS	Median	All	0.926	0.743	.026	3	view →
UCEC	OS	Quartile	All	1.000	0.846	.014	2	view →
LSCC	OS	Tertile	III,IV	0.986	0.476	.016	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SLC6A14–LUAD (OS)

Open the LUAD breakdown →