SLC6A14

Across TCGA patient cohorts, SLC6A14 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC6A14-associated genes across cancer lineages are eIF4E, FoxM1, and p38-MAPK_pT180_Y182. Each is linked with SLC6A14 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC6A14-to-partner and partner-to-SLC6A14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by SLC6A14-low versus SLC6A14-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC6A14→partner) and Y-score (partner→SLC6A14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.175	+3.598	.008	.001	3	2
UCEC	FoxM1 →	+0.162	+1.137	.046	.041	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.315	-1.874	.026	.049	3	2
UCEC	P-Cadherin →	-0.115	-2.584	.011	.010	3	2
UCEC	STAT3_pY705 →	-0.334	-1.514	<.001	.012	3	2
SKCM	CDK1 →	+0.171	+1.847	.007	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

eIF4E by SLC6A14 expression — UCEC

Explore this box plot interactively →