SLC6A1

Across TCGA patient cohorts, SLC6A1 mutation is significantly associated with the RNA expression of many other genes, with 5,318 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC6A1-associated genes across cancer lineages are KIF20A, ZWINT, and ERP27. Each is linked with SLC6A1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLC6A1-to-partner and partner-to-SLC6A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KIF20A grouped by SLC6A1-low versus SLC6A1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC6A1→partner) and Y-score (partner→SLC6A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	KIF20A →	+0.651	+1.680	<.001	<.001	3	3
UCEC	ZWINT →	+0.815	+1.847	<.001	<.001	3	3
COAD	ERP27 →	-1.228	-3.700	.002	.001	3	3
UCEC	PSMC3IP →	+0.737	+2.258	<.001	<.001	3	3
COAD	PSMC5 →	+0.336	+2.638	.009	.005	3	3
UCEC	PER1 →	+0.445	+1.534	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,318 associations by consensus.

KIF20A by SLC6A1 expression — UCEC

Explore this box plot interactively →