SLC6A1

Across TCGA patient cohorts, SLC6A1 mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC6A1-associated genes across cancer lineages are PDCD4, Annexin-1, and NDRG1_pT346. Each is linked with SLC6A1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLC6A1-to-partner and partner-to-SLC6A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by SLC6A1-low versus SLC6A1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC6A1→partner) and Y-score (partner→SLC6A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.389	-1.312	.005	.027	3	3
UCEC	Annexin-1 →	+0.811	+2.321	<.001	<.001	3	3
SKCM	NDRG1_pT346 →	-0.535	-3.321	.021	.009	3	3
COAD	EGFR_pY1068 →	-0.344	-2.309	.012	.033	3	2
UCEC	eIF4E →	+0.193	+2.392	.002	<.001	3	2
UCEC	PCNA →	+0.174	+1.584	.007	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

PDCD4 by SLC6A1 expression — UCEC

Explore this box plot interactively →