SLC6A1

Across TCGA cell cohorts, SLC6A1 mutation is significantly associated with the RNA expression of many other genes, with 421 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLC6A1-associated genes across cancer lineages are GSG1L2, PAX9, and MMP27. Each is linked with SLC6A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC6A1-to-partner and partner-to-SLC6A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSG1L2 grouped by SLC6A1-low versus SLC6A1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC6A1→partner) and Y-score (partner→SLC6A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GSG1L2 →	+0.028	+3.969	<.001	.009	3	2
LARGE_INTESTINE	PAX9 →	+0.691	+3.364	.005	.002	3	2
BLOOD_Leukemia	MMP27 →	+0.013	+3.969	<.001	.009	3	1
BLOOD_Leukemia	CPXCR1 →	+0.065	+3.971	.001	.002	3	1
BLOOD_Leukemia	FAM71B →	+0.015	+3.475	<.001	.006	3	1
BLOOD_Leukemia	RGS7 →	+0.302	+4.091	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 421 associations by consensus.

GSG1L2 by SLC6A1 expression — BLOOD_Leukemia

Explore this box plot interactively →