SLC66A3

Across TCGA pan-cancer cohorts, SLC66A3 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated SLC66A3 data layer compared with 22 for mass-spec protein.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher SLC66A3 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SLC66A3 expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

PDAC, GBM, and LUAD are the cancer types where SLC66A3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Quartile	All	0.316	0.756	.009	15	view →
GBM	DFS	Median	All	0.514	0.926	<.001	11	view →
LUAD	DFS	Median	All	1.000	0.628	.022	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

SLC66A3–PDAC (OS)

Open the PDAC breakdown →