SLC66A2

Across TCGA pan-cancer cohorts, SLC66A2 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated SLC66A2 data layer compared with 1 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher SLC66A2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SLC66A2 expression acts as an unfavorable survival marker, although some lineages such as UVM and KIRP show a favorable association.

ACC, UVM, and KIRP are the cancer types where SLC66A2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.234	0.686	<.001	110	view →
UVM	DFS	Median	III,IV	0.753	0.338	<.001	95	view →
KIRP	OS	Median	All	0.936	0.829	.001	54	view →
MESO	OS	Quartile	All	0.214	0.513	.001	24	view →
LAML	DFS	Quartile	All	0.385	0.695	.001	24	view →
BLCA	DFS	Quartile	All	0.265	0.483	.009	20	view →
UCS	OS	Tertile	IV	0.308	0.679	.024	18	view →
SCLC	DFS	Tertile	All	0.914	0.354	.006	17	view →
PRAD	DFS	Tertile	All	0.831	0.933	.002	16	view →
COAD	DFS	Quartile	II,III,IV	0.371	0.749	.008	14	view →
UCEC	DFS	Median	III,IV	0.850	0.735	.014	14	view →
KIRC	OS	Median	All	0.698	0.558	.007	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

SLC66A2–ACC (DFS)

Open the ACC breakdown →