SLC66A1L

Across TCGA patient cohorts, SLC66A1L mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC66A1L-associated genes across cancer lineages are EGFR_pY1068, JNK2, and Notch1. Each is linked with SLC66A1L in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC66A1L-to-partner and partner-to-SLC66A1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by SLC66A1L-low versus SLC66A1L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC66A1L→partner) and Y-score (partner→SLC66A1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.289	-3.459	.022	.005	3	1
UCEC	JNK2 →	+0.228	+3.009	.022	.019	3	1
UCEC	Notch1 →	+0.165	+2.321	.019	.035	3	1
UCEC	Shc_pY317 →	-0.182	-3.000	.017	.036	3	1
UCEC	VHL →	-0.875	-3.321	.010	.010	3	1
UCEC	PCNA →	+0.247	+2.321	.023	.035	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

EGFR_pY1068 by SLC66A1L expression — UCEC

Explore this box plot interactively →