SLC5A9

Across TCGA pan-cancer cohorts, SLC5A9 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated SLC5A9 data layer compared with 6 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher SLC5A9 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SLC5A9 expression acts as an unfavorable survival marker, although some lineages such as HNSC and READ show a favorable association.

LUSC, HNSC, and LGG are the cancer types where SLC5A9 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	DFS	Tertile	II,III,IV	0.270	0.496	<.001	71	view →
HNSC	DFS	Tertile	II,III,IV	0.455	0.264	.003	62	view →
LGG	DFS	Median	All	0.625	0.853	<.001	54	view →
READ	DFS	Tertile	III,IV	0.902	0.466	<.001	38	view →
UVM	OS	Median	III,IV	0.281	1.000	.003	29	view →
LIHC	DFS	Quartile	III,IV	0.076	0.440	.008	25	view →
THCA	OS	Quartile	II,III,IV	0.915	1.000	.006	21	view →
LUAD	DFS	Quartile	All	0.872	0.669	.004	21	view →
TGCT	DFS	Quartile	All	0.557	0.862	.007	18	view →
SCLC	DFS	Tertile	All	0.692	0.200	.027	18	view →
OV	DFS	Quartile	IV	0.353	0.585	.018	14	view →
THYM	OS	Median	All	0.921	1.000	.012	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

SLC5A9–LUSC (DFS)

Open the LUSC breakdown →