SLC5A7

Across TCGA patient cohorts, SLC5A7 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC5A7-associated genes across cancer lineages are TFRC, 4E-BP1_pT70, and Akt_pS473. Each is linked with SLC5A7 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLC5A7-to-partner and partner-to-SLC5A7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by SLC5A7-low versus SLC5A7-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC5A7→partner) and Y-score (partner→SLC5A7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TFRC →	+0.709	+3.000	.014	.036	3	3
UCEC	4E-BP1_pT70 →	+0.076	+1.222	.040	.035	3	3
LUAD	Akt_pS473 →	-0.532	-3.000	.009	.035	3	2
UCEC	FoxM1 →	+0.170	+1.459	.043	.012	3	2
UCEC	p62 Lck ligand →	+0.415	+2.594	<.001	<.001	3	2
UCEC	Shc_pY317 →	-0.183	-1.459	<.001	.012	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

TFRC by SLC5A7 expression — LUAD

Explore this box plot interactively →