SLC5A4

Across TCGA pan-cancer cohorts, SLC5A4 Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated SLC5A4 data layer compared with 25 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher SLC5A4 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated SLC5A4 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, BLCA, and LUAD are the cancer types where SLC5A4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	1.000	0.431	.004	34	view →
BLCA	OS	Median	All	0.069	0.688	<.001	18	view →
LUAD	OS	Median	All	0.558	0.814	.017	14	view →
LUSC	OS	Median	II,III,IV	0.322	0.635	.024	12	view →
HNSC	OS	Median	III,IV	0.156	0.673	.024	12	view →
ESCA	DFS	Median	II,III,IV	0.176	0.525	.024	12	view →
SKCM	DFS	Median	III,IV	0.016	0.648	<.001	12	view →
LGG	OS	Median	All	0.604	0.889	<.001	8	view →
TGCT	DFS	Median	All	0.014	0.837	<.001	6	view →
ACC	DFS	Median	All	0.089	0.666	.017	6	view →
STAD	OS	Median	III,IV	0.524	0.632	.022	4	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

SLC5A4–UCEC (DFS)

Open the UCEC breakdown →