Across TCGA pan-cancer cohorts, SLC5A3 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SLC5A3 data layer compared with 22 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher SLC5A3 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SLC5A3 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

CCRCC, LSCC, and PDAC are the cancer types where SLC5A3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Quartile	II,III,IV	0.554	0.954	.003	33	view →
LSCC	DFS	Median	II,III,IV	0.485	1.000	.006	7	view →
PDAC	DFS	Median	II,III,IV	0.325	1.000	.038	6	view →
HNSC	OS	Median	II,III,IV	1.000	0.939	.022	4	view →
LUAD	OS	Tertile	III,IV	0.948	0.472	.035	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: SLC5A3 tumor-vs-normal RNA expression · all SLC5A3 data types