SLC5A2

Across TCGA patient cohorts, SLC5A2 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC5A2-associated genes across cancer lineages are Cyclin-E1, INPP4B, and TSC1. Each is linked with SLC5A2 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLC5A2-to-partner and partner-to-SLC5A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-E1 grouped by SLC5A2-low versus SLC5A2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC5A2→partner) and Y-score (partner→SLC5A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Cyclin-E1 →	+0.254	+2.178	.031	.035	3	3
COAD	INPP4B →	-0.606	-3.321	<.001	.009	3	2
COAD	TSC1 →	-0.380	-3.313	.003	.010	3	2
UCEC	ATM →	-0.404	-1.662	.011	.011	3	2
COAD	Caspase-7-cleavedD198 →	+1.338	+3.330	<.001	.005	1	3
UCEC	JNK_pT183_Y185 →	-0.146	-1.700	.013	.042	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

Cyclin-E1 by SLC5A2 expression — COAD

Explore this box plot interactively →