SLC5A12

Across TCGA patient cohorts, SLC5A12 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC5A12-associated genes across cancer lineages are mTOR_pS2448, STAT3_pY705, and 4E-BP1. Each is linked with SLC5A12 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLC5A12-to-partner and partner-to-SLC5A12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by SLC5A12-low versus SLC5A12-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC5A12→partner) and Y-score (partner→SLC5A12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.113	-2.102	.044	.016	3	3
UCEC	STAT3_pY705 →	-0.302	-1.765	.002	.014	3	3
UCEC	4E-BP1 →	+0.376	+3.321	<.001	.009	3	3
UCEC	ASNS →	+0.353	+2.584	.009	.010	3	2
UCEC	Caspase-7-cleavedD198 →	+0.583	+2.135	.008	.010	3	2
LUAD	GSK-3_pS9 →	-0.516	-3.169	.009	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

mTOR_pS2448 by SLC5A12 expression — UCEC

Explore this box plot interactively →