SLC5A1

Across TCGA pan-cancer cohorts, SLC5A1 Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated SLC5A1 data layer compared with 23 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SLC5A1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SLC5A1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

HNSC, LUAD, and SKCM are the cancer types where SLC5A1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	II,III,IV	0.174	0.743	.002	21	view →
LUAD	OS	Median	All	0.285	0.677	.006	18	view →
SKCM	DFS	Median	All	0.283	0.772	<.001	16	view →
BLCA	OS	Median	IV	0.051	0.600	<.001	12	view →
UCEC	DFS	Median	All	0.965	0.614	.005	10	view →
LGG	OS	Median	All	0.182	0.909	<.001	8	view →
CESC	OS	Median	II,III,IV	0.203	0.759	.021	6	view →
CHOL	DFS	Median	All	0.037	0.486	.001	6	view →
STAD	OS	Median	II,III,IV	0.175	0.660	.005	6	view →
LIHC	OS	Median	All	0.101	0.780	<.001	6	view →
SARC	OS	Median	All	0.268	0.771	.016	3	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

SLC5A1–HNSC (OS)

Open the HNSC breakdown →