SLC5A1

Across TCGA patient cohorts, SLC5A1 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC5A1-associated genes across cancer lineages are FoxM1, PDCD4, and TFRC. Each is linked with SLC5A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC5A1-to-partner and partner-to-SLC5A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by SLC5A1-low versus SLC5A1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC5A1→partner) and Y-score (partner→SLC5A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.191	+1.584	.040	.019	3	2
UCEC	PDCD4 →	-0.582	-3.584	<.001	.002	3	2
UCEC	TFRC →	+0.609	+2.321	.001	.001	3	2
UCEC	ASNS →	+0.404	+1.584	.001	.034	3	2
UCEC	Caspase-7-cleavedD198 →	+0.720	+2.341	<.001	.003	3	2
LUSC	PARP_cleaved →	+0.484	+3.009	.023	.019	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

FoxM1 by SLC5A1 expression — UCEC

Explore this box plot interactively →