SLC5A1

Across TCGA cell cohorts, SLC5A1 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SLC5A1-associated genes across cancer lineages are OR10K2, TBC1D3H, and C7orf77. Each is linked with SLC5A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC5A1-to-partner and partner-to-SLC5A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10K2 grouped by SLC5A1-low versus SLC5A1-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC5A1→partner) and Y-score (partner→SLC5A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	OR10K2 →	+0.063	+5.781	<.001	.001	3	2
SKIN	TBC1D3H →	+0.648	+4.095	<.001	.009	3	1
SKIN	C7orf77 →	+0.066	+4.415	<.001	.007	3	1
LUNG_NSCLC_LUAD	TERB2 →	+0.017	+5.266	<.001	.001	3	1
LUNG_NSCLC_LUAD	SCYGR8 →	+0.017	+4.662	<.001	.005	3	1
BREAST	PABPC1L2A →	+0.083	+5.169	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

OR10K2 by SLC5A1 expression — BREAST

Explore this box plot interactively →