SLC52A3

Across TCGA patient cohorts, SLC52A3 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC52A3-associated genes across cancer lineages are MEK1, C-Raf, and FOXO3a_pS318_S321. Each is linked with SLC52A3 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLC52A3-to-partner and partner-to-SLC52A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by SLC52A3-low versus SLC52A3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC52A3→partner) and Y-score (partner→SLC52A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.514	+2.502	<.001	.002	3	3
COAD	C-Raf →	+0.246	+2.841	.002	.033	3	2
UCEC	FOXO3a_pS318_S321 →	-0.154	-3.797	.001	<.001	3	2
UCEC	mTOR_pS2448 →	-0.120	-1.584	.040	.036	3	2
UCEC	p21 →	+0.161	+3.459	.032	.005	3	2
UCEC	ATM →	-0.402	-1.584	.024	.036	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

MEK1 by SLC52A3 expression — UCEC

Explore this box plot interactively →