SLC52A3

Across TCGA cell cohorts, SLC52A3 mutation is significantly associated with the RNA expression of many other genes, with 30 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLC52A3-associated genes across cancer lineages are IL3, OR4N5, and PRAMEF10. Each is linked with SLC52A3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC52A3-to-partner and partner-to-SLC52A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL3 grouped by SLC52A3-low versus SLC52A3-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC52A3→partner) and Y-score (partner→SLC52A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	IL3 →	+0.042	+4.614	<.001	<.001	3	1
LUNG_SCLC	OR4N5 →	+0.024	+4.058	<.001	.007	3	1
LUNG_SCLC	PRAMEF10 →	+0.708	+4.058	<.001	.007	3	1
LUNG_SCLC	PRAMEF17 →	+0.008	+4.058	<.001	.007	3	1
LUNG_SCLC	PRAMEF14 →	+0.223	+3.523	<.001	.008	3	1
LARGE_INTESTINE	ZP2 →	+0.117	+3.000	.002	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

IL3 by SLC52A3 expression — LUNG_SCLC

Explore this box plot interactively →