SLC52A1

Across TCGA patient cohorts, SLC52A1 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC52A1-associated genes across cancer lineages are Rad50, FoxM1, and p62 Lck ligand. Each is linked with SLC52A1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLC52A1-to-partner and partner-to-SLC52A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rad50 grouped by SLC52A1-low versus SLC52A1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC52A1→partner) and Y-score (partner→SLC52A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rad50 →	-0.272	-2.700	.012	.006	3	3
UCEC	FoxM1 →	+0.302	+2.331	.009	.019	3	1
UCEC	p62 Lck ligand →	+0.381	+2.331	.009	.019	3	1
UCEC	PCNA →	+0.252	+3.321	.009	.009	3	1
UCEC	PDCD4 →	-0.450	-2.000	.034	.032	3	1
UCEC	Annexin-1 →	+0.541	+2.189	.022	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Rad50 by SLC52A1 expression — UCEC

Explore this box plot interactively →