Across TCGA pan-cancer cohorts, SLC51B RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of SLC51B’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where SLC51B RNA is repressed in tumor relative to normal tissue. In most cancer types SLC51B is over-expressed in tumor, although a few such as COAD and BLCA show the opposite, repressed pattern.

COAD, BLCA, and LUSC are the cancer types where SLC51B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SLC51B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	−4.464	<.001	12	view →
BLCA	Male	IV	−2.795	<.001	11	view →
LUSC	Female	II,III,IV	−3.461	<.001	9	view →
LIHC	All	III,IV	+2.592	<.001	9	view →
LUAD	Female	III,IV	−2.773	<.001	8	view →
UCEC	All	All	−2.466	<.001	8	view →
HNSC	Male	All	−0.540	<.001	8	view →
BRCA	All	III,IV	−0.938	<.001	6	view →
READ	All	II,III,IV	−4.590	<.001	5	view →
KICH	Female	All	−1.540	.002	4	view →
CHOL	All	II,III,IV	+1.309	.013	2	view →
KIRC	Male	All	−0.922	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

Exploration

Same gene, other analysis: SLC51B RNA expression & survival · all SLC51B data types