SLC4A8

Across TCGA pan-cancer cohorts, SLC4A8 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SLC4A8 data layer compared with 23 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher SLC4A8 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated SLC4A8 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, KIRP, and SKCM are the cancer types where SLC4A8 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.977	0.601	<.001	36	view →
KIRP	DFS	Median	II,III,IV	0.037	0.783	<.001	13	view →
SKCM	OS	Median	IV	0.589	0.754	.023	2	view →
LUAD	OS	Median	II,III,IV	0.472	0.716	.041	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SLC4A8–UCEC (DFS)

Open the UCEC breakdown →