SLC4A8

Across TCGA patient cohorts, SLC4A8 mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC4A8-associated genes across cancer lineages are eEF2, ACC1, and PI3K-p85. Each is linked with SLC4A8 in more than 4 cancer types. Because this analysis shows association rather than direction, both SLC4A8-to-partner and partner-to-SLC4A8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by SLC4A8-low versus SLC4A8-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC4A8→partner) and Y-score (partner→SLC4A8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	eEF2 →	+0.306	+3.178	.036	.010	1	5
SKCM	ACC1 →	+0.196	+1.530	.036	.003	3	2
SKCM	PI3K-p85 →	+0.145	+1.453	.022	.012	3	2
SKCM	Snail →	-0.130	-1.446	.011	.009	3	2
UCEC	Cyclin-B1 →	+0.666	+2.237	<.001	<.001	3	2
UCEC	GAPDH →	+0.333	+1.584	.029	.015	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

eEF2 by SLC4A8 expression — COAD

Explore this box plot interactively →