SLC4A8

Across TCGA cell cohorts, SLC4A8 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,644 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SLC4A8-associated GO terms across cancer lineages are Basolateral protein secretion, Centrosome cycle, and Positive regulation of smoothened signaling pathway. Each is linked with SLC4A8 in more than 11 cancer types. Because this analysis shows association rather than direction, both SLC4A8-to-partner and partner-to-SLC4A8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Basolateral protein secretion grouped by SLC4A8-low versus SLC4A8-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC4A8→partner) and Y-score (partner→SLC4A8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	Basolateral protein secretion →	-0.192	-0.917	.002	<.001	2	12
LUNG_SCLC	Centrosome cycle →	+0.084	+1.202	<.001	.001	3	10
LARGE_INTESTINE	Positive regulation of smoothened signaling pathway →	+0.075	+1.124	<.001	<.001	3	10
URINARY_TRACT	Regulation of hippocampal neuron apoptotic process →	-1.494	-1.065	<.001	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	Establishment of protein localization to organelle →	+0.047	+0.434	.001	.009	2	11
LUNG_SCLC	Cytoskeleton-dependent intracellular transport →	+0.090	+1.829	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,644 associations by consensus.

Basolateral protein secretion by SLC4A8 expression — BLOOD_Myeloma

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