SLC4A7

Across TCGA pan-cancer cohorts, SLC4A7 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of SLC4A7’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where SLC4A7 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types SLC4A7 is over-expressed in tumor, although a few such as COAD show the opposite, repressed pattern.

CCRCC, LSCC, and LUAD are the cancer types where SLC4A7 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SLC4A7 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Female	II,III,IV	+0.680	<.001	11	view →
LSCC	Female	II,III,IV	+0.613	<.001	9	view →
LUAD	Male	III,IV	+0.857	<.001	8	view →
COAD	Female	III,IV	−0.209	.008	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

SLC4A7–CCRCC

Open the CCRCC breakdown →