SLC4A7

Across TCGA patient cohorts, SLC4A7 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC4A7-associated genes across cancer lineages are ASNS, C-Raf, and JNK_pT183_Y185. Each is linked with SLC4A7 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLC4A7-to-partner and partner-to-SLC4A7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by SLC4A7-low versus SLC4A7-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC4A7→partner) and Y-score (partner→SLC4A7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ASNS →	+0.556	+2.593	<.001	.006	3	3
COAD	C-Raf →	+0.188	+3.356	.002	.004	3	3
UCEC	JNK_pT183_Y185 →	-0.132	-1.353	.004	.013	3	3
UCEC	p21 →	+0.116	+1.925	.028	.004	3	3
UCEC	PDCD4 →	-0.473	-2.048	<.001	<.001	3	2
COAD	Smad4 →	+0.201	+3.321	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

ASNS by SLC4A7 expression — COAD

Explore this box plot interactively →