SLC4A7

Across TCGA cell cohorts, SLC4A7 mutation is significantly associated with the mutation status of many other genes, with 5,750 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLC4A7-associated genes across cancer lineages are PCDHA5, TMEM132A, and AHI1. Each is linked with SLC4A7 in more than 3 cancer types. Because this analysis shows association rather than direction, both SLC4A7-to-partner and partner-to-SLC4A7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCDHA5 grouped by SLC4A7-low versus SLC4A7-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC4A7→partner) and Y-score (partner→SLC4A7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	PCDHA5 →	+2.906	+2.554	.006	.006	1	4
BLOOD_Leukemia	TMEM132A →	+3.080	+2.675	.004	.004	1	4
LARGE_INTESTINE	AHI1 →	+4.793	+3.196	<.001	<.001	1	4
SKIN	MBD6 →	+4.392	+4.392	.009	.009	1	4
SKIN	EFCAB5 →	+3.392	+4.718	.002	.002	1	4
BLOOD_Leukemia	MYH9 →	+2.232	+2.282	.006	.006	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,750 associations by consensus.

PCDHA5 by SLC4A7 expression — CNS

Explore this box plot interactively →