SLC4A4

Across TCGA pan-cancer cohorts, SLC4A4 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SLC4A4 data layer compared with 27 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher SLC4A4 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated SLC4A4 expression acts as an unfavorable survival marker, although some lineages such as GBM and PDAC show a favorable association.

GBM, PDAC, and CCRCC are the cancer types where SLC4A4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	OS	Median	All	0.696	0.393	<.001	14	view →
PDAC	DFS	Tertile	II,III,IV	0.503	0.294	.010	10	view →
CCRCC	OS	Median	All	0.984	0.906	.033	4	view →
LSCC	DFS	Median	III,IV	1.000	0.623	.032	3	view →
LUAD	OS	Tertile	III,IV	0.840	0.246	.008	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SLC4A4–GBM (OS)

Open the GBM breakdown →