SLC4A4

Across TCGA patient cohorts, SLC4A4 mutation is significantly associated with the total protein of many other genes, with 61 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC4A4-associated genes across cancer lineages are PKC-delta_pS664, PCNA, and 4E-BP1. Each is linked with SLC4A4 in more than 3 cancer types. Because this analysis shows association rather than direction, both SLC4A4-to-partner and partner-to-SLC4A4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PKC-delta_pS664 grouped by SLC4A4-low versus SLC4A4-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC4A4→partner) and Y-score (partner→SLC4A4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	PKC-delta_pS664 →	-0.157	-2.972	.034	.036	3	4
UCEC	PCNA →	+0.152	+1.206	.010	.009	3	4
STAD	4E-BP1 →	+0.312	+3.169	.033	.018	3	3
COAD	Caspase-7-cleavedD198 →	+1.421	+3.178	<.001	.010	3	3
LUSC	MYH11 →	-1.464	-2.990	.002	.036	3	2
LUSC	CD49b →	+0.625	+3.009	<.001	.019	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 61 associations by consensus.

PKC-delta_pS664 by SLC4A4 expression — LUSC

Explore this box plot interactively →