SLC4A4

Across TCGA cell cohorts, SLC4A4 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,682 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SLC4A4-associated GO terms across cancer lineages are Regulation of hydrogen peroxide biosynthetic process, Positive regulation of pinocytosis, and Cytokinesis. Each is linked with SLC4A4 in more than 7 cancer types. Because this analysis shows association rather than direction, both SLC4A4-to-partner and partner-to-SLC4A4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of hydrogen peroxide biosynthetic process grouped by SLC4A4-low versus SLC4A4-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC4A4→partner) and Y-score (partner→SLC4A4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Regulation of hydrogen peroxide biosynthetic process →	+0.175	+0.930	<.001	<.001	3	8
SOFT_TISSUE	Positive regulation of pinocytosis →	+0.129	+1.477	<.001	.001	3	8
SKIN	Cytokinesis →	+0.033	+0.527	.002	<.001	3	8
SOFT_TISSUE	Protein localization to early endosome →	+0.206	+1.081	<.001	<.001	3	8
BONE	Regulation of cell-substrate junction organization →	+0.127	+1.294	<.001	<.001	3	8
BONE	Regulation of cellular response to growth factor stimulus →	+0.058	+1.523	.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,682 associations by consensus.

Regulation of hydrogen peroxide biosynthetic process by SLC4A4 expression — BLOOD_Leukemia

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