SLC4A3

Across TCGA patient cohorts, SLC4A3 mutation is significantly associated with the RNA expression of many other genes, with 4,845 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC4A3-associated genes across cancer lineages are EXO1, KNSTRN, and CENPU. Each is linked with SLC4A3 in more than 4 cancer types. Because this analysis shows association rather than direction, both SLC4A3-to-partner and partner-to-SLC4A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EXO1 grouped by SLC4A3-low versus SLC4A3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC4A3→partner) and Y-score (partner→SLC4A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EXO1 →	+0.626	+2.212	<.001	<.001	3	5
UCEC	KNSTRN →	+0.449	+2.076	<.001	.001	3	5
UCEC	CENPU →	+0.662	+1.617	<.001	<.001	3	4
STAD	MIER3 →	+0.640	+3.476	<.001	.002	3	4
COAD	SNRPD1 →	+0.421	+3.209	.008	.009	3	4
STAD	GLOD4 →	+0.622	+3.509	<.001	.002	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,845 associations by consensus.

EXO1 by SLC4A3 expression — UCEC

Explore this box plot interactively →