SLC4A3

Across TCGA cell cohorts, SLC4A3 mutation is significantly associated with the RNA expression of many other genes, with 576 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SLC4A3-associated genes across cancer lineages are H2BW2, CUEDC2, and TSHB. Each is linked with SLC4A3 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLC4A3-to-partner and partner-to-SLC4A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, H2BW2 grouped by SLC4A3-low versus SLC4A3-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC4A3→partner) and Y-score (partner→SLC4A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	H2BW2 →	+0.036	+3.672	.001	.006	3	3
LARGE_INTESTINE	CUEDC2 →	+0.517	+3.234	.004	.004	3	2
LARGE_INTESTINE	TSHB →	+0.025	+2.540	<.001	.007	3	2
LARGE_INTESTINE	FAM117B →	+0.634	+2.628	.002	.002	3	2
LARGE_INTESTINE	GID4 →	+0.712	+3.526	<.001	<.001	3	2
LARGE_INTESTINE	LYG1 →	+1.076	+3.743	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 576 associations by consensus.

H2BW2 by SLC4A3 expression — BREAST

Explore this box plot interactively →