SLC4A2

Across TCGA patient cohorts, SLC4A2 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC4A2-associated genes across cancer lineages are mTOR_pS2448, Caspase-7-cleavedD198, and PCNA. Each is linked with SLC4A2 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLC4A2-to-partner and partner-to-SLC4A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by SLC4A2-low versus SLC4A2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC4A2→partner) and Y-score (partner→SLC4A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.105	-1.986	.029	.029	3	3
UCEC	Caspase-7-cleavedD198 →	+0.795	+2.019	<.001	.001	3	3
COAD	PCNA →	+0.385	+2.815	.004	.036	3	2
UCEC	Fibronectin →	-0.244	-1.755	.022	.013	3	2
UCEC	PDK1_pS241 →	+0.124	+1.502	.025	.027	3	2
UCEC	STAT3_pY705 →	-0.306	-1.652	<.001	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

mTOR_pS2448 by SLC4A2 expression — UCEC

Explore this box plot interactively →