SLC4A2

Across TCGA cell cohorts, SLC4A2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,122 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible SLC4A2-associated GO terms across cancer lineages are Regulation of enamel mineralization, Positive regulation of enamel mineralization, and Pre-mRNA catabolic process. Each is linked with SLC4A2 in more than 13 cancer types. Because this analysis shows association rather than direction, both SLC4A2-to-partner and partner-to-SLC4A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of enamel mineralization grouped by SLC4A2-low versus SLC4A2-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC4A2→partner) and Y-score (partner→SLC4A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Regulation of enamel mineralization →	+0.408	+1.771	<.001	<.001	3	14
LUNG_NSCLC_LUSC	Positive regulation of enamel mineralization →	+0.393	+1.602	<.001	<.001	3	14
BONE	Pre-mRNA catabolic process →	+0.199	+0.983	.002	.001	3	11
SOFT_TISSUE	Positive regulation of intracellular estrogen receptor signaling pathway →	+0.140	+0.983	<.001	<.001	3	10
CNS	Regulation of isotype switching to IgG isotypes →	+0.105	+0.892	<.001	<.001	3	10
LARGE_INTESTINE	Regulation of modification of synaptic structure →	+0.097	+0.619	<.001	.004	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,122 associations by consensus.

Regulation of enamel mineralization by SLC4A2 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →