SLC4A1

Across TCGA pan-cancer cohorts, SLC4A1 Mutation is linked to patient survival in 12 of 34 cancer types, making it a survival-associated SLC4A1 data layer compared with 22 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in rectum adenocarcinoma (READ), where higher SLC4A1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SLC4A1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

READ, PAAD, and LUSC are the cancer types where SLC4A1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
READ	OS	Median	II,III,IV	0.111	0.919	<.001	30	view →
PAAD	DFS	Median	All	0.133	0.486	.005	18	view →
LUSC	OS	Median	II,III,IV	0.418	0.739	.009	12	view →
UCEC	DFS	Median	All	0.966	0.618	.010	12	view →
LIHC	OS	Median	All	0.064	0.781	<.001	9	view →
UVM	OS	Median	All	0.249	0.712	.033	6	view →
CESC	DFS	Median	II,III,IV	0.136	0.711	<.001	6	view →
COAD	OS	Median	III,IV	0.237	0.798	<.001	6	view →
LUAD	DFS	Median	IV	0.342	0.893	<.001	6	view →
STAD	DFS	Median	All	0.169	0.539	.040	6	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →
PRAD	DFS	Median	All	0.234	0.781	.005	2	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

SLC4A1–READ (OS)

Open the READ breakdown →