SLC4A1

Across TCGA pan-cancer cohorts, SLC4A1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated SLC4A1 data layer compared with 22 for mass-spec protein and 12 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher SLC4A1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SLC4A1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and COAD show a favorable association.

CCRCC, COAD, and PDAC are the cancer types where SLC4A1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	0.920	0.691	.001	29	view →
COAD	DFS	Median	III,IV	1.000	0.835	.032	18	view →
PDAC	DFS	Quartile	All	0.322	0.575	.005	15	view →
LUAD	DFS	Tertile	III,IV	0.460	0.995	.013	10	view →
UCEC	DFS	Quartile	III,IV	0.355	1.000	.040	8	view →
HNSC	OS	Tertile	All	0.897	0.783	.030	4	view →
LSCC	DFS	Tertile	III,IV	0.686	1.000	.044	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

SLC4A1–CCRCC (DFS)

Open the CCRCC breakdown →