SLC4A1

Across TCGA patient cohorts, SLC4A1 mutation is significantly associated with the RNA expression of many other genes, with 2,418 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC4A1-associated genes across cancer lineages are GOT1, MRM3, and TSPY26P. Each is linked with SLC4A1 in more than 3 cancer types. Because this analysis shows association rather than direction, both SLC4A1-to-partner and partner-to-SLC4A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GOT1 grouped by SLC4A1-low versus SLC4A1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC4A1→partner) and Y-score (partner→SLC4A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	GOT1 →	+0.444	+3.114	.001	<.001	3	4
COAD	MRM3 →	+0.451	+2.428	<.001	.002	3	4
COAD	TSPY26P →	-0.712	-2.401	<.001	.003	3	4
BRCA	SNORD90 →	+0.290	+3.332	<.001	.009	3	3
CESC	LINC02854 →	+0.032	+5.000	<.001	.001	3	3
UCEC	GOT2 →	+0.409	+2.906	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,418 associations by consensus.

GOT1 by SLC4A1 expression — COAD

Explore this box plot interactively →