SLC4A1

Across TCGA patient cohorts, SLC4A1 mutation is significantly associated with the total protein of many other genes, with 68 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC4A1-associated genes across cancer lineages are Caspase-7-cleavedD198, 4E-BP1, and GATA3. Each is linked with SLC4A1 in more than 3 cancer types. Because this analysis shows association rather than direction, both SLC4A1-to-partner and partner-to-SLC4A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by SLC4A1-low versus SLC4A1-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC4A1→partner) and Y-score (partner→SLC4A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Caspase-7-cleavedD198 →	+0.987	+3.000	.010	.034	2	4
STAD	4E-BP1 →	+0.416	+3.000	.007	.034	3	3
UCEC	GATA3 →	+0.144	+1.939	.034	.003	3	3
STAD	beta-Catenin →	+0.833	+3.000	.026	.036	3	2
STAD	Cyclin-B1 →	+0.587	+3.000	.014	.036	1	4
COAD	ACC_pS79 →	-0.238	-1.691	.037	.043	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 68 associations by consensus.

Caspase-7-cleavedD198 by SLC4A1 expression — STAD

Explore this box plot interactively →