SLC4A1

Across TCGA cell cohorts, SLC4A1 mutation is significantly associated with the RNA expression of many other genes, with 93 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLC4A1-associated genes across cancer lineages are SIRPD, CPXCR1, and ODF1. Each is linked with SLC4A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC4A1-to-partner and partner-to-SLC4A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SIRPD grouped by SLC4A1-low versus SLC4A1-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC4A1→partner) and Y-score (partner→SLC4A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SIRPD →	+0.058	+5.029	<.001	.006	3	1
BLOOD_Leukemia	CPXCR1 →	+0.084	+4.234	<.001	<.001	3	1
BLOOD_Leukemia	ODF1 →	+0.086	+3.266	<.001	.003	3	1
BLOOD_Leukemia	C8A →	+0.016	+3.269	<.001	.007	3	1
BLOOD_Leukemia	DEFB4A →	+0.086	+3.269	<.001	.007	3	1
BLOOD_Leukemia	AQP12A →	+0.089	+3.269	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 93 associations by consensus.

SIRPD by SLC4A1 expression — LUNG_SCLC

Explore this box plot interactively →