SLC4A1

Across TCGA cell cohorts, SLC4A1 mutation is significantly associated with the mutation status of many other genes, with 3,215 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SLC4A1-associated genes across cancer lineages are NCKAP5, ABCC12, and POLQ. Each is linked with SLC4A1 in more than 4 cancer types. Because this analysis shows association rather than direction, both SLC4A1-to-partner and partner-to-SLC4A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NCKAP5 grouped by SLC4A1-low versus SLC4A1-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC4A1→partner) and Y-score (partner→SLC4A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	NCKAP5 →	+3.345	+3.882	.001	.001	1	5
OVARY	ABCC12 →	+3.930	+3.632	.003	.003	1	5
LUNG_SCLC	POLQ →	+2.552	+4.157	.003	.003	1	5
SOFT_TISSUE	SHANK1 →	+4.502	+5.066	.007	.007	1	5
SOFT_TISSUE	ABCC8 →	+5.502	+5.502	.003	.003	1	5
SOFT_TISSUE	KDM5A →	+5.502	+5.502	.003	.003	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,215 associations by consensus.

NCKAP5 by SLC4A1 expression — OVARY

Explore this box plot interactively →