SLC46A3

Across TCGA pan-cancer cohorts, SLC46A3 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of SLC46A3’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SLC46A3 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types SLC46A3 is over-expressed in tumor, although a few such as LSCC and LUAD show the opposite, repressed pattern.

HNSC, LSCC, and LUAD are the cancer types where SLC46A3 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SLC46A3 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	+1.243	.002	6	view →
LSCC	All	II,III,IV	−0.750	<.001	5	view →
LUAD	Male	III,IV	−0.381	.016	3	view →
PDAC	Male	III,IV	−0.477	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

SLC46A3–HNSC

Open the HNSC breakdown →