SLC46A2

Across TCGA patient cohorts, SLC46A2 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC46A2-associated genes across cancer lineages are Caspase-7-cleavedD198, eEF2, and MSH2. Each is linked with SLC46A2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC46A2-to-partner and partner-to-SLC46A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by SLC46A2-low versus SLC46A2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC46A2→partner) and Y-score (partner→SLC46A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.745	+2.827	.022	.035	3	2
LUSC	eEF2 →	+0.230	+2.816	.022	.036	3	1
UCEC	MSH2 →	-0.479	-2.973	<.001	.035	3	1
UCEC	PDCD4 →	-0.652	-3.169	.011	.020	3	1
UCEC	PRAS40_pT246 →	+0.260	+3.000	.005	.036	3	1
LUSC	G6PD →	+0.542	+2.816	.032	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

Caspase-7-cleavedD198 by SLC46A2 expression — UCEC

Explore this box plot interactively →