SLC46A2

Across TCGA cell cohorts, SLC46A2 mutation is significantly associated with the RNA expression of many other genes, with 50 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLC46A2-associated genes across cancer lineages are NKX2-6, TLE7, and TNRC6B. Each is linked with SLC46A2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC46A2-to-partner and partner-to-SLC46A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NKX2-6 grouped by SLC46A2-low versus SLC46A2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC46A2→partner) and Y-score (partner→SLC46A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	NKX2-6 →	+0.591	+5.201	<.001	.006	3	1
BLOOD_Leukemia	TLE7 →	+0.042	+5.969	<.001	.001	3	1
LARGE_INTESTINE	TNRC6B →	+0.834	+3.064	.001	.009	3	1
LARGE_INTESTINE	MOGAT1 →	+0.089	+2.556	<.001	.006	3	1
LARGE_INTESTINE	RIPK1 →	+0.598	+3.201	.006	.006	3	1
LARGE_INTESTINE	LIMD1 →	+0.717	+3.067	.002	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

NKX2-6 by SLC46A2 expression — BLOOD_Leukemia

Explore this box plot interactively →