SLC46A1

Across TCGA patient cohorts, SLC46A1 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC46A1-associated genes across cancer lineages are eEF2, ERK2, and JNK_pT183_Y185. Each is linked with SLC46A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC46A1-to-partner and partner-to-SLC46A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by SLC46A1-low versus SLC46A1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC46A1→partner) and Y-score (partner→SLC46A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.384	+2.459	.026	.020	3	1
UCEC	ERK2 →	+0.210	+2.459	.024	.020	3	1
UCEC	JNK_pT183_Y185 →	-0.232	-3.571	.004	.002	3	1
UCEC	JNK2 →	+0.256	+2.179	.007	.034	3	1
UCEC	MSH2 →	-0.279	-2.973	.012	.035	3	1
UCEC	Myosin-IIa →	+0.236	+2.818	.011	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

eEF2 by SLC46A1 expression — UCEC

Explore this box plot interactively →