SLC45A3

Across TCGA pan-cancer cohorts, SLC45A3 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SLC45A3 data layer compared with 22 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher SLC45A3 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated SLC45A3 expression acts as an unfavorable survival marker, although some lineages such as BLCA and LUSC show a favorable association.

SKCM, BLCA, and LUAD are the cancer types where SLC45A3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	DFS	Median	All	0.053	0.757	<.001	18	view →
BLCA	DFS	Median	All	1.000	0.615	.025	9	view →
LUAD	OS	Median	II,III,IV	0.158	0.749	.010	9	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
LUSC	DFS	Median	All	1.000	0.384	.033	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SLC45A3–SKCM (DFS)

Open the SKCM breakdown →